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In the tree of life, human evolution is a very unusual case in many ways. If the focus of study is too narrow, it is difficult to avoid special pleading. My long-term research strategy has hence been rooted in the conviction that a wide-ranging approach is essential to identify reliable general principles. Secure interpretation of our biological origins demands comprehensive study of primate evolution from its earliest beginnings. In this spirit, I have conducted sweeping comparisons across primates, covering anatomy of both living and fossil representatives, ecology, behaviour, reproduction and molecular evolution. Study of size relationships (allometric scaling) has been a pervasive theme. A synthetic approach to primate evolution has several benefits. In addition to generating sound general principles, it can reveal relationships that otherwise escape detection.